教室紹介

教官・病院スタッフ

広瀬　貴行

助教

広瀬　貴行Takayuki Hirose

専門領域

腎移植血管外科

資格

  • 日本泌尿器科学会認定医
  • 日本泌尿器科学会認定専門医
  • 日本泌尿器内視鏡学会腹腔鏡技術認定医
  • 日本移植学会移植認定医
  • 臨床腎移植学会認定医

卒業年次

2006年　北海道大学卒、2017年　北海道大学大学院卒

出身地

北海道札幌出身

職歴

2006年3月
北海道大学医学部医学科卒業
北海道内の関連施設にて泌尿器科一般の臨床に従事
2014年4月-2016年3月
広島大学消化器・移植外科にて移植免疫の研究に従事
2017年3月
北海道大学大学院　修了
2019年4月-2021年9月
米国ハーバード大学医学部マサチューセッツ総合病院にて移植免疫（免疫寛容及び異種移植）の研究に従事
2021年10月-2022年3月
自治医科大学泌尿器科学講座腎臓外科部門　助教
2022年4月
北海道大学病院血液浄化部　助教

所属学会

  • 日本泌尿器科学会
  • 日本移植学会
  • 日本臨床腎移植学会
  • 日本泌尿器内視鏡学会
  • 日本小児腎不全学会
  • 日本透析医学会
  • アメリカ移植学会
  • 国際移植学会
  • 国際異種移植学会
  • 国際小児移植学会

受賞歴

  • 2013年　日本泌尿器内視鏡学: Young Endourologist Award
  • 2015年　Transplantation Science Symposium: Scientific Travel Grant Award
  • 2017年　アメリカ移植学会: Best Poster Award
  • 2018年　Transplantation Science symposium Asian Regional Meeting: Travel Grant Award
  • 2021年　国際異種移植学会: Scientific Congress Award
  • 2022年　日本臓器保存生物医学会：会長賞
  • 2023年　日本異種移植研究会：学会賞
  • 2023年　日本臓器保存生物医学会：会長賞

主要論文

  1. Hirose T, Tanaka Y, Tanaka A, Sakai H, Sasaki Y, Shinohara N, Ohdan H. PD-L1/PD-L2-expressing B-1 Cells Inhibit Alloreactive T Cells in Mice. PLoS One. 2017 Jun 1;12(6):e0178765
  2. Hirose T, Hotta K, Iwami D, Harada H, Morita K, Tanabe T, Sasaki H, Fukuzawa N, Seki T, Shinohara N. Safety and Efficacy of Retroperitoneoscopic Living Donor Nephrectomy: Comparison of Early Complication, Donor and Recipient Outcome with Hand-Assisted Laparoscopic Living Donor Nephrectomy. J Endourol. 2018; 32(12):1120-1124.
  3. Hirose T, Iwami D, Hotta K, Sasaki H, Higuchi H, Shinohara N. Percentage of CD19+ cells in Peripheral Blood Lymphocytes after Rituximab-based Desensitization as a Predictor of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation. Transplant Proc. 2019 Jun; 51(5): 1382-1386
  4. Hirose T, Ma D, Lassiter G, Sasaki H, Rosales I, Coe TM, Rickert CG, Matheson R, Colvin RB, Qin W, Kan Y, Layer JV, Paragas VB, Stiede K, Hall KC, Youd ME, Queiroz LM, Westlin WF, Curtis M, Yang L, Markmann JF, Kawai T. Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques. American Journal of Transplantation. 2022 Jan;22(1):46-57. doi: 10.1111/ajt.16780.
  5. Takayuki Hirose, Kiyohiko Hotta, Hiroshi Harada, Tatsu Tanabe, Hajime Sasaki, and Nobuo Shinohara. Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival. Int J Urol 29, 7 (2022), 699–706.
  6. Hirose T, Sasaki H, Oura T, Otsuka R, Rosales I, Ma D, Lassiter G, Karadagi A, Tomosugi T, Dehnadi A, Matsunami M, Paul SR, Reeves PM, Hanekamp I, Schwartz S, Colvin RB, Lee H, Spitzer TR, Cosimi AB, Cippà PE, Fehr T, Kawai T. Selective Bcl-2 inhibition promotes hematopoietic chimerism and allograft tolerance without myelosuppression in nonhuman primates. Sci Transl Med. 2023;15(690).
  7. Hirose T, Lassiter G, Otsuka R, Rosales I, Karadagi A, Tomosugi T, Dehnadi A, Lee H, Colvin RB, Baardsnes J, Moraitis A, Smith EE, Ali Z, Berhe P, Mulder A, Meibohm B, Daugherty B, Fogarty S, Pierson RN, Lederman S, Kawai T. TNX-1500, an Fc-modified Anti-CD154 Antibody, Prolongs Nonhuman Primate Renal Allograft Survival. Am J Transplant. 2023;23(8):1171-1181. doi:10.1016/j.ajt.2023.03.022
  8. Hirose T, Anand RP, Layer JV, Heja D, Lassiter G, Firl DJ, Paragas VB, Akkad A, Chhangawala S, Colvin RB, Ernst RJ, Esch N, Getchell K, Griffin AK, Guo X, Hall KC, Hamilton P, Kalekar LA, Kan Y, Karadagi A, Li F, Low SC, Matheson R, Nehring C, Otsuka R, Pandelakis M, Policastro RA, Pols R, Queiroz L, Rosales IA, Serkin WT, Stiede K, Tomosugi T, Xue Y, Zentner GE, Angeles-Albores D, Chao JC, Crabtree JN, Harken S, Hinkle N, Lemos T, Li M, Pantano L, Stevens D, Subedar OD, Tan X, Yin S, Anwar IJ, Aufhauser D, Capuano S, Kaufman DB, Knechtle SJ, Kwun J, Shanmuganayagam D, Markmann JF, Church GM, Curtis M, Kawai T, Youd ME, Qin W. Design and testing of a humanized porcine donor for xenotransplantation. Nature. 2023;622(7982):393-401.
  9. Hirose T, Hotta K, Osawa T, Yokota I, Inao T, Tanabe T, Iwahara N, Shinohara N. Longitudinal mortality risks and kidney functional outcomes in Japanese living kidney donors. Int J Urol. Published online 2024. doi:10.1111/iju.15395

業績

  • Hirose T, Ma D, Lassiter G, Sasaki H, Rosales I, Coe TM, Rickert CG, Matheson R, Colvin RB, Qin W, Kan Y, Layer JV, Paragas VB, Stiede K, Hall KC, Youd ME, Queiroz LM, Westlin WF, Curtis M, Yang L, Markmann JF, Kawai T. Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques. American Journal of Transplantation. 2022 Jan;22(1):46-57. doi: 10.1111/ajt.16780. [5Y-IF: 4.349]
  • Hirose T, Hotta K, Harada H, Tanabe T, Sasaki H, Shinohara N. Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival. Int J Urol. 2022;29(7):699-706. doi:10.1111/iju.14876
  • Hirose T, Hotta K, Shinohara N. Response to [Letter to the Editor on ‘Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival.’] Int J Urol. 2022;29(10):1245-1246. doi:10.1111/iju.15002
  • Hotta K, Hirose T, Kawai T. Int J Urol. Clinical trials for renal allograft tolerance induction through combined hematopoietic stem cell transplantation: A narrative review. 2022;29(12):1397-1404. doi:10.1111/iju.15035
  • Iwahara N, Hotta K, Hirose T, Shinohara N. Long-Term Results in Recipients of Late Conversion to a Calcineurin Inhibitor-Free Regimen with Everolimus After Kidney Transplantation. Transplant P. 2023;55(4):803-808. doi:10.1016/j.transproceed.2023.04.008
  • Iwahara N, Hotta K, Iwami D, Tanabe T, Tanaka Y, Ito YM, Otsuka T, Murai S, Takada Y, Higuchi H, Sasaki H, Hirose T, Harada H, Shinohara N. Analysis of T-cell alloantigen response via a direct pathway in kidney transplant recipients with donor-specific antibodies. Front Immunol. 2023;14:1164794.
  • Hirose T, Sasaki H, Oura T, Otsuka R, Rosales I, Ma D, Lassiter G, Karadagi A, Tomosugi T, Dehnadi A, Matsunami M, Paul SR, Reeves PM, Hanekamp I, Schwartz S, Colvin RB, Lee H, Spitzer TR, Cosimi AB, Cippà PE, Fehr T, Kawai T. Selective Bcl-2 inhibition promotes hematopoietic chimerism and allograft tolerance without myelosuppression in nonhuman primates. Sci Transl Med. 2023;15(690).
  • Hirose T, Lassiter G, Otsuka R, Rosales I, Karadagi A, Tomosugi T, Dehnadi A, Lee H, Colvin RB, Baardsnes J, Moraitis A, Smith EE, Ali Z, Berhe P, Mulder A, Meibohm B, Daugherty B, Fogarty S, Pierson RN, Lederman S, Kawai T. TNX-1500, an Fc-modified Anti-CD154 Antibody, Prolongs Nonhuman Primate Renal Allograft Survival. Am J Transplant. 2023;23(8):1171-1181. doi:10.1016/j.ajt.2023.03.022
  • Firl DJ, Lassiter G, Hirose T, Policastro R, D’Attilio A, Markmann JF, Kawai T, Hall KC. Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation. Nat Commun. 2023;14(1):3022.
  • Nonoyama S, Hotta K, Iwahara N, Tanabe T, Hirose T, Harada S, Junichi S, Nakazawa D, Shigematsu A, Otsuka T, Shinohara N. Nephron. Use of Mixed Lymphocyte Reaction Assay to Evaluate Immune Tolerance before Kidney Transplantation with an Immunosuppression-Free Protocol following Hematopoietic Stem Cell Transplantation from the Same Donor. 2023;147(10):621-626. doi:10.1159/000531031
  • Hosokawa C, Hotta K, Okamoto T, Cho Y, Hirose T, Iwahara N, Manabe A, Shinohara N. Prophylactic bilateral nephrectomy and preemptive kidney transplantation for Denys–Drash syndrome prior to development of kidney failure.
    Pediatr Nephrol. 2024;39(3):905-909. doi:10.1007/s00467-023-06113-7
  • Hirose T, Anand RP, Layer JV, Heja D, Lassiter G, Firl DJ, Paragas VB, Akkad A, Chhangawala S, Colvin RB, Ernst RJ, Esch N, Getchell K, Griffin AK, Guo X, Hall KC, Hamilton P, Kalekar LA, Kan Y, Karadagi A, Li F, Low SC, Matheson R, Nehring C, Otsuka R, Pandelakis M, Policastro RA, Pols R, Queiroz L, Rosales IA, Serkin WT, Stiede K, Tomosugi T, Xue Y, Zentner GE, Angeles-Albores D, Chao JC, Crabtree JN, Harken S, Hinkle N, Lemos T, Li M, Pantano L, Stevens D, Subedar OD, Tan X, Yin S, Anwar IJ, Aufhauser D, Capuano S, Kaufman DB, Knechtle SJ, Kwun J, Shanmuganayagam D, Markmann JF, Church GM, Curtis M, Kawai T, Youd ME, Qin W. Design and testing of a humanized porcine donor for xenotransplantation. Nature. 2023;622(7982):393-401.
  • Hirose T, Hotta K, Osawa T, Yokota I, Inao T, Tanabe T, Iwahara N, Shinohara N. Longitudinal mortality risks and kidney functional outcomes in Japanese living kidney donors. Int J Urol. Published online 2024. doi:10.1111/iju.15395

業績

2022年度年報 掲載分
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